A robust ransac-based planet radius estimation for onboard visual based navigation

Individual spacecraft manual navigation by human operators from ground station is expected to be an emerging problem as the number of spacecraft for space exploration increases. Hence, as an attempt to reduce the burden to control multiple spacecraft, future missions will employ smart spacecraft able to navigate and operate autonomously. Recently, image-based optical navigation systems have proved to be promising solutions for inexpensive autonomous navigation. In this paper, we propose a robust image processing pipeline for estimating the center and radius of planets and moons in an image taken by an on-board camera. Our custom image pre-processing pipeline is tailored for resource-constrained applications, as it features a computationally simple processing flow with a limited memory footprint. The core of the proposed pipeline is a best-fitting model based on the RANSAC algorithm that is able to handle images corrupted with Gaussian noise, image distortions, and frame drops. We report processing time, pixel-level error of estimated body center and radius and the effect of noise on estimated body parameters for a dataset of synthetic images

Clinical characteristics and outcome of patients with autoimmune hemolytic anemia (AIHA) uniformly defined as primary by a diagnostic work-up

Primary autoimmune hemolytic anemia (P-AIHA) is a relatively uncommon and hetereogeneous disease characterized by the destruction of red blood cells due to anti-erythrocyte autoantibodies (AeAbs) in the absence of an associated disease [1–3]. Secondary AHIA is frequently associated with lymphoproliferative diseases (LD) in particular, chronic lymphocytic leukemia, aggressive or indolent lymphomas, autoimmune disorders, malignancies other than lymphoid, and infections [1,2,4]. On the hypothetical assumption that in a significant proportion of cases defined as P-AIHA the clinical heterogeneity could be due to an ignored associated disease, we retrospectively analyzed the clinical characteristics and outcome of patients with a diagnosis of P-AIHA based on a diagnostic work-up aimed at excluding or identifying an associated disease. ..

CloudScout: A deep neural network for on-board cloud detection on hyperspectral images

The increasing demand for high-resolution hyperspectral images from nano and microsatellites conflicts with the strict bandwidth constraints for downlink transmission. A possible approach to mitigate this problem consists in reducing the amount of data to transmit to ground through on-board processing of hyperspectral images. In this paper, we propose a custom Convolutional Neural Network (CNN) deployed for a nanosatellite payload to select images eligible for transmission to ground, called CloudScout. The latter is installed on the Hyperscout-2, in the frame of the Phisat-1 ESA mission, which exploits a hyperspectral camera to classify cloud-covered images and clear ones. The images transmitted to ground are those that present less than 70% of cloudiness in a frame. We train and test the network against an extracted dataset from the Sentinel-2 mission, which was appropriately pre-processed to emulate the Hyperscout-2 hyperspectral sensor. On the test set we achieve 92% of accuracy with 1% of False Positives (FP). The Phisat-1 mission will start in 2020 and will operate for about 6 months. It represents the first in-orbit demonstration of Deep Neural Network (DNN) for data processing on the edge. The innovation aspect of our work concerns not only cloud detection but in general low power, low latency, and embedded applications. Our work should enable a new era of edge applications and enhance remote sensing applications directly on-board satellite

Neural stem cell transplantation for neurodegenerative diseases

Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms, such as the production of neurotrophic factors, decreased neuroinflammation, enhanced neuronal plasticity and cell replacement. Thus, NSC transplantation may represent an effective therapeutic strategy. To exploit NSCs\u2019 potential, some of their essential biological characteristics must be thoroughly investigated, including the specific markers for NSC subpopulations, to allow profiling and selection. Another key feature is their secretome, which is responsible for the regulation of intercellular communication, neuroprotection, and immunomodulation. In addition, NSCs must properly migrate into the central nervous system (CNS) and integrate into host neuronal circuits, enhancing neuroplasticity. Understanding and modulating these aspects can allow us to further exploit the therapeutic potential of NSCs. Recent progress in gene editing and cellular engineering techniques has opened up the possibility of modifying NSCs to express select candidate molecules to further enhance their therapeutic effects. This review summarizes current knowledge regarding these aspects, promoting the development of stem cell therapies that could be applied safely and effectively in clinical settings

New insights into the structure of early-type galaxies: the Photometric Plane at z~0.3

We study the Photometric Plane (PHP), namely the relation between the effective radius re, the mean surface brightness within that radius e, and the Sersic index n, in optical (R and I) and near-infrared (K) bands for a large sample of early-type galaxies (ETGs) in the rich cluster MS1008-1224 at z=0.306. The PHP relation has an intrinsic dispersion of ~32% in re, and turns out to be independent of waveband. This result is consistent with the fact that internal colour gradients of ETGs can have only a mild dependence on galaxy luminosity (mass). There is no evidence for a significant curvature in the PHP. We show that this can be explained if this relation origins from a systematic variation of the specific entropy of ETGs along the galaxy sequence, as was suggested from previous works. The intrinsic scatter of the PHP is significantly smaller than for other purely photometric relations, such as the Kormendy relation and the photometric Fundamental Plane, which is constructed by using colours in place of velocity dispersions. The scatter does not depend on the waveband and the residuals about the plane do not correlate with residuals of the colour-magnitude relation. Finally, we compare the coefficients of the PHP at z~0.3 with those of ETGs at z~0, showing that the PHP is a valuable tool to constrain the luminosity evolution of ETGs with redshift. The slopes of the PHP do not change significantly with redshift, while the zero-point is consistent with cosmological dimming of the surface brightness in an expanding universe plus the passive fading of galaxy stellar populations with a high formation redshift (z_f >1-2).Comment: 21 pages, 10 figures, MNRAS in pres

Effect of axial coordination on the kinetics of assembly and folding of the two halves of horse heart cytochrome c

The kinetics of the assembly of two complementary fragments of oxidized horse heart cytochrome c (cyt c), namely the heme-containing fragment-(1-56) and the fragment-(57-104), have been characterized at different pH values. At neutral pH the fragment-(1-56) is hexacoordinated and has two histidines axially ligated to the heme-Fe(III) (Santucci, R., Fiorucci, L., Sinibaldi, F., Polizio, F., Desideri, A., and Ascoli, F. (2000) Arch. Biochem. Biophys. 379, 331-336), thus mimicking what occurs in the folding intermediate of cyt c. The kinetics of the formation of the complex between the two fragments are characterized at pH 7.0 by a slow rate constant that is independent of the concentration of the reactants; conversely, at a low pH the kinetics are much faster and depend on the concentration of the fragments. This behavior suggests that the rate-limiting step observed in the recombination process of the fragments at neutral pH (that leads to the final coordination of Met-80) has to be ascribed to the detachment of the "misligated" histidine. Thus, the faster recombination rate at a low pH can be related to the fact that histidine is protonated and not able to coordinate to the metal. Furthermore, the independence of the rate constant on the concentration of the reactants observed at pH 7.0 can be accounted for by the occurrence of a conformational transition, which takes place immediately after the two fragments collapse together, likely simulating what induces the detachment of the misligated histidine during cytochrome folding

High resolution radio continuum survey of M33: I. The radio maps

We study the exponential scale length of total radio emission, the spectral index distribution, and the linear radio polarization in the Scd galaxy M33. Observations were carried out using the 3.6 cm dual channel and the 6.2 cm four channel receivers of the 100--m Effelsberg telescope along with the L-band VLA D--array at 20 cm. High spatial resolution and sensitivity in both total and linearly polarized radio continuum emission from M33 were achieved. We found considerable extended emission, not only from the main arms I S and I N, but also from the weaker arms. The large--scale magnetic field exhibits well--ordered spiral structure with almost the same orientation as that of the optical spiral arms, however, it does not show a clear structural correlation or anti--correlation with the optical arms. There is a north-south asymmetry in polarization that is frequency-dependent. We found that the ring mean spectral index versus radius increases faster beyond $R$ = 4 kpc. At each wavelength, the exponential scale length is larger inside than outside $R$ = 4 kpc. From the larger scales lengths at $R$ $<$ 4 kpc, we conclude that star forming regions are mainly spread over the region $R$ $<$ 4 kpc without a dominant nuclear concentration. Furthermore, at $R$ $<$ 4 kpc, a spatial correlation between cosmic rays and star forming regions may exist. From the behaviour of the mean spectral indices obtained from different pairs of the radio continuum data at 3.6, 6.2, and 20 cm, we confirm that a decrease in the thermal fraction causes an increase in the spectral index. The frequency-dependent asymmetry in the polarization hints to an asymmetry in Faraday depolarization.Comment: 16 pages, 13 figures, accepted for publication in the Astronomy and Astrophysics Journa

Does the site of origin of the microcarcinoma with respect to the thyroid surface matter? A multicenter pathologic and clinical study for risk stratification

It is unclear whether the site of origin of papillary thyroid microcarcinoma (mPTC) with respect to the thyroid surface has an influence on clinicopathologic parameters. The objectives of the study were to: (i) Accurately measure the mPTC distance from the thyroid surface; (ii) analyze whether this distance correlates with relevant clinicopathologic parameters; and (iii) investigate the impact of the site of origin of the mPTC on risk stratification. Clinicopathologic features and BRAF mutational status were analyzed and correlated with the site of origin of the mPTC in a multicenter cohort of 298 mPTCs from six Italian medical institutions. Tumors arise at a median distance of 3.5 mm below the surface of the thyroid gland. Statistical analysis identified four distinct clusters. Group A, mPTC: size 65 5 mm and distance of the edge of the tumor from the thyroid capsule = 0 mm; group B, mPTC: size 65 5 mm and distance of the edge of the tumor from the thyroid capsule &gt; 0 mm; group C, mPTC: size &lt; 5 mm and distance of the edge of the tumor from the thyroid capsule = 0 mm; and group D, mPTC: size &lt; 5 mm and distance of the edge of the tumor from the thyroid capsule &gt; 0 mm. Univariate analysis demonstrates significant differences between the groups: Group A shows the most aggressive features, and group D the most indolent ones. By multivariate analysis, group A tumors are characterized by tall cell histotype, BRAF V600E mutation, tumor fibrosis, aggressive growth with invasive features, vascular invasion, lymph node metastases, and intermediate ATA risk. The mPTC clinicopathologic features vary according to the tumor size and distance from the thyroid surface. A four-group model may be useful for risk stratification and to refine the selection of nodules to be targeted for fine needle aspiration